Netspot neoendocrine tumor santa fe9/17/2023 ![]() ![]() Accurate diagnostic tests will help to diagnose NETs earlier and potentially prevent carcinoid heart disease, bowel obstruction, and improve quality of life and mortality in these patients. They can be confused with an allergic reaction and the allergist should consider it as a differential diagnosis. NETs can present as carcinoid syndrome (flushing, diarrhea, abdominal pain, wheezing), which constitutes vague symptomatology and represents a challenging diagnosis for physicians. He was started on octreotide and underwent a wide hepatectomy and right hemicolectomy with improvement of symptoms. Hepatic and intestinal biopsies reported a well-differentiated NET of the ileocecal valve with hepatic metastasis. The CT scan showed thickening of the distal ileum and multiple lesions on both hepatic lobules and the colonoscopy revealed a tumor in the ileocecal valve. The 24-h urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion was elevated. He denied abdominal pain, diarrhea, cough or wheezing. We present the case of a 17-year-old male with evanescent non-pruriginous erythematous lesions- flushing that appeared with food consumption, associated with conjunctival injection, warmth and diaphoresis after the lesions disappeared. ![]() We present the case of a pediatric patient initially referred under the suspicion of food allergies. CS can be confused with an allergic reaction and thus should be considered as a differential diagnosis in the allergy consult. Small bowel NETs (SB-NETs) are related to serotonin hypersecretion which causes: flushing, diarrhea, abdominal pain, bronchoconstriction and heart involvement, also known as carcinoid syndrome (CS). This information is important for planning the appropriate course of therapy.Neuroendocrine tumors (NETs) are heterogeneous neoplasms that originate from cells with a secretory function. “Netspot provides another diagnostic tool whose results will help clinicians determine the location and extent of the tumor. “Use of advanced imaging techniques to detect rare neuroendocrine tumors at an early stage in patients is critical,” Libero Marzella, MD, PhD, director of the Division of Medical Imaging Products in the FDA’s Center for Drug Evaluation and Research, said in a press release. The studies reported no serious adverse reactions. The FDA based its approval on positive safety and efficacy results from three studies - the first compared Ga 68 dotatate images of neuroendocrine tumors to images obtained with an approved drug, which were then confirmed with CT or MRI the second study evaluated Ga 68 dotatate images using histopathology or clinical follow-up and the third study evaluated patients with neuroendocrine tumor recurrence using Ga 68 dotatate images. Netspot (Advanced Accelerator Applications USA) - a sterile, single-dose kit for the preparation of gallium Ga 68 dotatate intravenous injection, a radioactive diagnostic agent for PET imaging - is indicated to help locate tumors in adult and pediatric patients with somatostatin receptor positive neuroendocrine tumors. ![]() The FDA approved the diagnostic imaging agent Netspot to detect rare neuroendocrine tumors. If you continue to have this issue please contact to Healio ![]()
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